Chalcone: a privileged structure in medicinal chemistry
Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …
Recent developments in biological activities of chalcones: A mini review
Chalcones represent key structural motif in the plethora of biologically active molecules
including synthetic and natural products. Synthetic manipulations of chalcones or their …
including synthetic and natural products. Synthetic manipulations of chalcones or their …
Anti-cancer chalcones: Structural and molecular target perspectives
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …
molecule are basically designed to interact with multiple targets or to amplify its effect …
Exploring pharmacological significance of chalcone scaffold: a review
NK Sahu, SS Balbhadra… - Current medicinal …, 2012 - ingentaconnect.com
Chalcones (1, 3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the
flavonoid family, which possess a number of interesting biological properties such as …
flavonoid family, which possess a number of interesting biological properties such as …
Advances in chalcones with anticancer activities
C Karthikeyan, N SH Narayana Moorthy… - Recent patents on …, 2015 - ingentaconnect.com
Chalcones are naturally occurring compounds exhibiting broad spectrum biological
activities including anticancer activity through multiple mechanisms. Literature on anticancer …
activities including anticancer activity through multiple mechanisms. Literature on anticancer …
Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure‐activity relationship
F Gao, G Huang, J Xiao - Medicinal research reviews, 2020 - Wiley Online Library
The continuous emergency of drug‐resistant cancers and the low specificity of anticancer
agents have been the major challenges in the control and treatment of cancer, making an …
agents have been the major challenges in the control and treatment of cancer, making an …
Chalcones with electron-withdrawing and electron-donating substituents: anticancer activity against TRAIL resistant cancer cells, structure–activity relationship …
In the present study, a series of 46 chalcones were synthesised and evaluated for
antiproliferative activities against the human TRAIL-resistant breast (MCF-7, MDA-MB-231) …
antiproliferative activities against the human TRAIL-resistant breast (MCF-7, MDA-MB-231) …
Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death
MW Robinson, JH Overmeyer, AM Young… - Journal of medicinal …, 2012 - ACS Publications
Methuosis is a novel caspase-independent form of cell death in which massive
accumulation of vacuoles derived from macropinosomes ultimately causes cells to detach …
accumulation of vacuoles derived from macropinosomes ultimately causes cells to detach …
A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells
JH Overmeyer, AM Young, H Bhanot, WA Maltese - Molecular cancer, 2011 - Springer
Background Methuosis is a unique form of non-apoptotic cell death triggered by alterations
in the trafficking of clathrin-independent endosomes, ultimately leading to extreme …
in the trafficking of clathrin-independent endosomes, ultimately leading to extreme …