Label-free biomedical optical imaging

NT Shaked, SA Boppart, LV Wang, J Popp - Nature photonics, 2023 - nature.com
Label-free optical imaging employs natural and non-destructive approaches to visualize
biomedical samples for both biological assays and clinical diagnosis. At present, this field …

Quantitative phase imaging trends in biomedical applications

T Cacace, V Bianco, P Ferraro - Optics and Lasers in Engineering, 2020 - Elsevier
In the last decades, the understanding of the complex biological mechanisms that regulate
the life and growth of single cells and their reciprocal interaction has steadily increased. In …

Roadmap on digital holography-based quantitative phase imaging

V Balasubramani, M Kujawińska, C Allier, V Anand… - Journal of …, 2021 - mdpi.com
Quantitative Phase Imaging (QPI) provides unique means for the imaging of biological or
technical microstructures, merging beneficial features identified with microscopy …

Digital holographic deep learning of red blood cells for field-portable, rapid COVID-19 screening

T O'Connor, JB Shen, BT Liang, B Javidi - Optics Letters, 2021 - opg.optica.org
Rapid screening of red blood cells for active infection of COVID-19 is presented using a
compact and field-portable, 3D-printed shearing digital holographic microscope. Video …

TOP-GAN: Stain-free cancer cell classification using deep learning with a small training set

M Rubin, O Stein, NA Turko, Y Nygate, D Roitshtain… - Medical image …, 2019 - Elsevier
We propose a new deep learning approach for medical imaging that copes with the problem
of a small training set, the main bottleneck of deep learning, and apply it for classification of …

Deep learning-based cell identification and disease diagnosis using spatio-temporal cellular dynamics in compact digital holographic microscopy

T O'Connor, A Anand, B Andemariam… - Biomedical Optics …, 2020 - opg.optica.org
We demonstrate a successful deep learning strategy for cell identification and disease
diagnosis using spatio-temporal cell information recorded by a digital holographic …

Tomographic phase microscopy with 180 rotation of live cells in suspension by holographic optical tweezers

M Habaza, B Gilboa, Y Roichman, NT Shaked - Optics letters, 2015 - opg.optica.org
We present a new tomographic phase microscopy (TPM) approach that allows capturing the
three-dimensional refractive index structure of single cells in suspension without labeling …

Real‐time stain‐free classification of cancer cells and blood cells using interferometric phase microscopy and machine learning

N Nissim, M Dudaie, I Barnea, NT Shaked - Cytometry Part A, 2021 - Wiley Online Library
We present a method for real‐time visualization and automatic processing for detection and
classification of untreated cancer cells in blood during stain‐free imaging flow cytometry …

PARC: ultrafast and accurate clustering of phenotypic data of millions of single cells

SV Stassen, DMD Siu, KCM Lee, JWK Ho… - …, 2020 - academic.oup.com
Motivation New single-cell technologies continue to fuel the explosive growth in the scale of
heterogeneous single-cell data. However, existing computational methods are inadequately …

Wavefront microscopy using quadriwave lateral shearing interferometry: From bioimaging to nanophotonics

G Baffou - ACS photonics, 2023 - ACS Publications
Common cameras are only sensitive to the intensity of light, discarding an essential feature
of a light wave: its phase profile or, equivalently, its wavefront profile. This Review focuses …