Noncancerous disease-targeting AIEgens

Y Duo, G Luo, W Zhang, R Wang, GG Xiao… - Chemical Society …, 2023 - pubs.rsc.org
Noncancerous diseases include a wide plethora of medical conditions beyond cancer and
are a major cause of mortality around the world. Despite progresses in clinical research …

Fluorescent probes for organelle-targeted bioactive species imaging

P Gao, W Pan, N Li, B Tang - Chemical science, 2019 - pubs.rsc.org
Bioactive species, including reactive oxygen species (ROS, including O2˙−, H2O2, HOCl,
1O2,˙ OH, HOBr, etc.), reactive nitrogen species (RNS, including ONOO−, NO, NO2, HNO …

Progress and trends in AIE-based bioprobes: a brief overview

J Mei, Y Huang, H Tian - ACS applied materials & interfaces, 2017 - ACS Publications
Luminescent bioprobes are powerful analytical means for biosensing and optical imaging.
Luminogens featured with aggregation-induced emission (AIE) attributes have emerged as …

Aggregation-induced emission: a trailblazing journey to the field of biomedicine

C Zhu, RTK Kwok, JWY Lam… - ACS Applied Bio Materials, 2018 - ACS Publications
The emergence of the aggregation-induced emission (AIE) concept significantly changes
the cognition of the scientific community toward classic photophysical phenomena. More …

Aggregation-induced emission photosensitizers: from molecular design to photodynamic therapy: miniperspective

J Dai, X Wu, S Ding, X Lou, F Xia… - Journal of medicinal …, 2020 - ACS Publications
Photodynamic therapy (PDT) has emerged as a promising noninvasive treatment option for
cancers and other diseases. The key factor that determines the effectiveness of PDT is the …

AIE luminogens as fluorescent bioprobes

G Niu, R Zhang, X Shi, H Park, S Xie, RTK Kwok… - TrAC Trends in …, 2020 - Elsevier
Organic fluorescent bioprobes provide robust and powerful analytical techniques for direct
detection and monitoring of important biological species and their related biological …

Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting

X Fu, Y Shi, T Qi, S Qiu, Y Huang, X Zhao… - Signal transduction and …, 2020 - nature.com
Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to
reach their final targets. The optimal targets of most cancer therapeutic agents are usually …

An Intracellular H2O2‐Responsive AIEgen for the Peroxidase‐Mediated Selective Imaging and Inhibition of Inflammatory Cells

Y Cheng, J Dai, C Sun, R Liu, T Zhai… - Angewandte Chemie …, 2018 - Wiley Online Library
Inflammatory cells have gained widespread attention because inflammatory diseases
increase the risk for many types of cancer. Therefore, it is urgent and important to implement …

Modular design of peptide-or DNA-modified AIEgen probes for biosensing applications

F Xia, J Wu, X Wu, Q Hu, J Dai… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Fluorophore probes are widely used for bioimaging in cells, tissues, and
animals as well as for monitoring of multiple biological processes in complex environments …

A multifunctional peptide‐conjugated AIEgen for efficient and sequential targeted gene delivery into the nucleus

Y Cheng, C Sun, R Liu, J Yang, J Dai… - Angewandte …, 2019 - Wiley Online Library
Gene therapy has immense potential as a therapeutic approach to serious diseases.
However, efficient delivery and real‐time tracking of gene therapeutic agents have not been …