Glucagon is historically described as the counterregulatory hormone to insulin, induced by
fasting/hypoglycemia to raise blood glucose through action mediated in the liver. However, it …

Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the
hypoglycemic action of insulin and strongly contributes to the correction of acute …

Paracrine interactions between pancreatic islet cells have been proposed as a mechanism
to regulate hormone secretion and glucose homeostasis. Here, we demonstrate the …

In this work, poly (ethylene glycol)-b-poly [3-acrylamidophenylboronic acid-co-styrene](PEG-
bP (PBA-co-St) has been firstly synthesized for loading of insulin to form insulin-loaded …

Hyperglucagonemia, a hallmark in obesity and insulin resistance promotes hepatic glucose
output, exacerbating hyperglycemia and thus predisposing to the development type 2 …

Metabolic-associated steatotic liver disease (MASLD) is closely associated with obesity.
MASLD affects over 1 billion adults globally but there are few treatment options available …

Skin regeneration of full-thickness wounds remains a challenge, requiring a well-regulated
interplay of cell–cell and cell–matrix signaling. Herein, the composite hydrogel films …

The pancreatic islet is a dense cellular network comprised of several cell types with
endocrine function vital in the control of glucose homeostasis, metabolism, and feeding …

While the consumption of external energy (ie, feeding) is essential to life, this action induces
a temporary disturbance of homeostasis in an animal. A primary example of this effect is …

As an incretin hormone, glucagon-like peptide 1 (GLP-1) lowers blood glucose levels by
enhancing glucose-stimulated insulin secretion from pancreatic beta-cells. Therapies …