Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

Parkinson's disease is a progressive neuropathological disorder that belongs to the class of
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders with a
global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

In 2017, it is two hundred years since James Parkinson provided the first complete clinical
description of the disease named after him, fifty years since the introduction of high-dose D …

Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological
diseases including Parkinson's disease (PD). Previously, we reported the structure of alpha …