The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their
cellular responses by binding to and activating the different isoforms encoded by the four …

Background The late-onset cerebellar ataxias (LOCAs) have largely resisted molecular
diagnosis. Methods We sequenced the genomes of six persons with autosomal dominant …

Adult-onset cerebellar ataxias are a group of neurodegenerative conditions that challenge
both genetic discovery and molecular diagnosis. In this study, we identified an intronic (GAA) …

In mammals, fibroblast growth factors (FGFs) are encoded by 22 genes. FGFs bind and
activate alternatively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1–4). The …

The autosomal dominant cerebellar ataxias (ADCAs) represent a heterogeneous group of
neurodegenerative diseases with progressive ataxia and cerebellar degeneration. The …

The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-
γ coactivator-1α (PGC-1α) was targeted in mice. PGC-1α null (PGC-1α−/−) mice were viable …

Fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling plays
essential roles in bone development and diseases. Missense mutations in FGFs and FGFRs …

In many species, the Sox2 transcription factor is a marker of the nervous system from the
beginning of its development, and we have previously shown that Sox2 is expressed in …

Binding of the transcription factor nuclear factor E2-related factor 2 (Nrf2) to the antioxidant
response element (ARE) in neural cells results in the induction of a battery of genes that can …