Lysophospholipid receptors

N Fukushima, I Ishii, JJA Contos… - Annual review of …, 2001 - annualreviews.org
Lysophospholipids (LPs), including lysophosphatidic acid and sphingosine 1-phosphate,
produce many cellular effects. However, the prolonged absence of any cloned and identified …

Characterization of the human cysteinyl leukotriene CysLT1 receptor

KR Lynch, GP O'neill, Q Liu, DS Im, N Sawyer… - Nature, 1999 - nature.com
The cysteinyl leukotrienes—leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene
E4 (LTE4)—are important mediators of human bronchial asthma,,,. Pharmacological studies …

Characterization of the human cysteinyl leukotriene 2 receptor

CE Heise, BF O'Dowd, DJ Figueroa, N Sawyer… - Journal of Biological …, 2000 - ASBMB
The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC 4, LTD
4, and LTE 4, are thought to be mediated through at least two distinct but related CysLT G …

Fingolimod: lessons learned and new opportunities for treating multiple sclerosis and other disorders

J Chun, Y Kihara, D Jonnalagadda… - Annual review of …, 2019 - annualreviews.org
Fingolimod (FTY720, Gilenya) was the first US Food and Drug Administration–approved oral
therapy for relapsing forms of multiple sclerosis (MS). Research on modified fungal …

Lysophosphatidic acid signaling in cancer cells: what makes LPA so special?

P Balijepalli, CC Sitton, KE Meier - Cells, 2021 - mdpi.com
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …

Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate

DS Im, CE Heise, MA Harding, SR George… - Molecular …, 2000 - Elsevier
Two G protein-coupled receptors (Edg-2) and (Edg-4) for the lysolipid phosphoric acid
mediator lysophosphatidic acid have been described by molecular cloning. However, the …

A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells: cross-talk between cyclic AMP and protein …

Z Gao, T Chen, MJ Weber, J Linden - Journal of Biological Chemistry, 1999 - ASBMB
Mitogen-activated protein kinase (MAPK) cascades underlie long-term mitogenic,
morphogenic, and secretory activities of purinergic receptors. In HEK-293 cells, N …

Synthesis, structure− activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARγ, and …

GG Durgam, T Virag, MD Walker… - Journal of medicinal …, 2005 - ACS Publications
We previously reported that fatty alcohol phosphates (FAP) represent a minimal
pharmacophore required to interact with lysophosphatidic acid (LPA) receptors. To improve …

Structure− activity analysis of the effects of lysophosphatidic acid on platelet aggregation

G Gueguen, B Gaigé, JM Grévy, P Rogalle, J Bellan… - Biochemistry, 1999 - ACS Publications
Lysophosphatidic acid (1-acyl-sn-glycero-3-phosphate or LPA) is a phospholipid mediator
displaying numerous and widespread biological activities and thought to act via G-protein …

[引用][C] Lysophosphatidic acid receptors

JJA Contos, I Ishii, J Chun - Molecular pharmacology, 2000 - ASPET