[HTML][HTML] Mitochondrial complex I ROS production and redox signaling in hypoxia

CN Okoye, SA Koren, AP Wojtovich - Redox biology, 2023 - Elsevier
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is
the major process of aerobic respiration. Enzyme complexes of the electron transport chain …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

The integrated brain network that controls respiration

F Krohn, M Novello, RS van der Giessen, CI De Zeeuw… - Elife, 2023 - elifesciences.org
Respiration is a brain function on which our lives essentially depend. Control of respiration
ensures that the frequency and depth of breathing adapt continuously to metabolic needs. In …

Making sense of astrocytic calcium signals—from acquisition to interpretation

A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …

Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

N Marina, IN Christie, A Korsak, M Doronin… - Nature …, 2020 - nature.com
Astrocytes provide neurons with essential metabolic and structural support, modulate
neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to …

Calcium signaling in astrocytes and gliotransmitter release

J Goenaga, A Araque, P Kofuji… - Frontiers in synaptic …, 2023 - frontiersin.org
Glia are as numerous in the brain as neurons and widely known to serve supportive roles
such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and …

Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle

SM Theparambil, PS Hosford, I Ruminot… - Nature …, 2020 - nature.com
Brain cells continuously produce and release protons into the extracellular space, with the
rate of acid production corresponding to the levels of neuronal activity and metabolism …

Stratification of astrocytes in healthy and diseased brain

A Verkhratsky, R Zorec, V Parpura - Brain Pathology, 2017 - Wiley Online Library
Astrocytes, a subtype of glial cells, come in variety of forms and functions. However,
overarching role of these cell is in the homeostasis of the brain, be that regulation of ions …

[HTML][HTML] The SLC9A-C mammalian Na+/H+ exchanger family: molecules, mechanisms, and physiology

SF Pedersen, L Counillon - Physiological reviews, 2019 - journals.physiology.org
Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

The retrotrapezoid nucleus: central chemoreceptor and regulator of breathing automaticity

PG Guyenet, RL Stornetta, GMPR Souza… - Trends in …, 2019 - cell.com
The ventral surface of the rostral medulla oblongata has been suspected since the 1960s to
harbor central respiratory chemoreceptors [ie, acid-activated neurons that regulate breathing …