Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

TonB-dependent transporters (TBDTs) are present in all gram-negative bacteria and
mediate energy-dependent uptake of molecules that are too scarce or large to be taken up …

Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …

Siderophores are iron-chelating molecules that solubilize Fe 3+ for microbial utilization and
facilitate colonization or infection of eukaryotes by liberating host iron for bacterial uptake. By …

The design and synthesis of narrow-spectrum antibiotics that target a specific bacterial
strain, species, or group of species is a promising strategy for treating bacterial infections …

We studied the Escherichia coli outer membrane protein Fiu, a presumed transporter of
monomeric ferric catecholates, by introducing Cys residues in its surface loops and …

Iron is an essential growth factor for bacteria, but although highly abundant in nature, its
bioavailability during infection in the human host or the environment is limited. Therefore …

Siderophores are low-molecular-weight organic compounds produced by bacteria and fungi
for Fe (III) supply. Bacteria and fungi biosynthesize siderophores in response to low iron …

Microbes synthesize and secrete siderophores, that bind and solubilize precipitated or
otherwise unavailable iron in their microenvironments. Gram (−) bacterial TonB-dependent …

为维持生长所需, 革兰氏阴性菌需要从外界摄取多种营养物质. 分子量小于600 Da
的分子可以通过自由扩散的方式通过革兰氏阴性菌的外膜, 而大分子物质则需要特殊的转运系统 …