Transcriptional and epigenetic regulation of oligodendrocyte development and myelination in the central nervous system
Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …
orchestrated process involving well-defined steps from specification of neural stem cells into …
Neuron-oligodendrocyte interactions in the structure and integrity of axons
The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …
Oligodendrocytes and axons have a reciprocal signaling relationship in which …
[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease
MI Gabitto, KJ Travaglini, VM Rachleff, ES Kaplan… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
Regulation of prefrontal cortex myelination by the microbiota
The prefrontal cortex (PFC) is a key region implicated in a range of neuropsychiatric
disorders such as depression, schizophrenia and autism. In parallel, the role of the gut …
disorders such as depression, schizophrenia and autism. In parallel, the role of the gut …
Motor skill learning requires active central myelination
Myelin-forming oligodendrocytes (OLs) are formed continuously in the healthy adult brain. In
this work, we study the function of these late-forming cells and the myelin they produce …
this work, we study the function of these late-forming cells and the myelin they produce …
Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning
L Xiao, D Ohayon, IA McKenzie, A Sinclair-Wilson… - Nature …, 2016 - nature.com
We identified mRNA encoding the ecto-enzyme Enpp6 as a marker of newly forming
oligodendrocytes, and used Enpp6 in situ hybridization to track oligodendrocyte …
oligodendrocytes, and used Enpp6 in situ hybridization to track oligodendrocyte …
Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain
C Creeley, K Dikranian, G Dissen… - British journal of …, 2013 - academic.oup.com
Background Exposure of the fetal or neonatal non-human primate (NHP) brain to isoflurane
or ketamine for 5 h causes widespread apoptotic degeneration of neurones, and exposure …
or ketamine for 5 h causes widespread apoptotic degeneration of neurones, and exposure …
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration
S Moyon, AL Dubessy, MS Aigrot, M Trotter… - Journal of …, 2015 - Soc Neuroscience
The declining efficiency of myelin regeneration in individuals with multiple sclerosis has
stimulated a search for ways by which it might be therapeutically enhanced. Here we have …
stimulated a search for ways by which it might be therapeutically enhanced. Here we have …
Mechanisms regulating the development of oligodendrocytes and central nervous system myelin
Oligodendrocytes and the myelin they produce are a remarkable vertebrate specialization
that enables rapid and efficient nerve conduction within the central nervous system. The …
that enables rapid and efficient nerve conduction within the central nervous system. The …
MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes
H Bujalka, M Koenning, S Jackson, VM Perreau… - PLoS …, 2013 - journals.plos.org
The myelination of axons is a crucial step during vertebrate central nervous system (CNS)
development, allowing for rapid and energy efficient saltatory conduction of nerve impulses …
development, allowing for rapid and energy efficient saltatory conduction of nerve impulses …