Staphylococcus aureus is a formidable pathogen capable of causing infections in different
sites of the body in a variety of vertebrate animals, including humans and livestock. A major …

T lymphocytes comprise cells expressing either an αβ or a γδ TCR. The riddle how αβ TCRs
are triggered by specific peptides presented in the context of MHC was elucidated some …

The oral cavity is inhabited by a wide spectrum of microbial species, and their colonization is
mostly based on commensalism. These microbes are part of the normal oral flora, but there …

Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …

Nonclonal innate immune responses mediated by germ line–encoded receptors, such as
Toll-like receptors or natural killer receptors, are commonly contrasted with diverse …

Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disease
occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C …

The globally prominent pathogen Streptococcus pyogenes secretes potent
immunomodulatory proteins known as superantigens (SAgs), which engage lateral surfaces …

Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger
excessive stimulation of human and other mammalian T lymphocytes. This leads to a …

Staphylococcus aureus superantigens (SAgs) are among the most potent T cell mitogens
known. They stimulate large fractions of T cells by cross-linking their T cell receptor with …

Staphylococcus aureus is a successful human and animal pathogen. Its pathogenicity is
linked to its ability to secrete a large amount of virulence factors. These secreted proteins …