Epithelial cells exfoliated in human urine can include cells anywhere from the urinary tract
and kidneys; however, podocytes and proximal tubular epithelial cells (PTECs) are by far the …

Focal segmental glomerulosclerosis (FSGS) is a common glomerular injury leading to end-
stage renal disease. Monogenic FSGS is primarily ascribed to decreased podocyte integrity …

Transient receptor potential cation channel-6 (TRPC6) gene mutations cause familial focal
segmental glomerulosclerosis (FSGS), which is inherited as an autosomal dominant …

Glomerular diseases are a leading cause of chronic kidney disease worldwide. Both
acquired and hereditary glomerulopathies frequently share a common final disease …

Despite considerable advances in prevention, diagnosis, and therapy, nephrotic syndrome
(NS) remains a significant cause of high morbidity and mortality globally. As a result, there is …

Mutations in TRPC6 are a cause of autosomal dominant focal segmental glomerulosclerosis
in humans. Many of these mutations are known to have a gain-of-function effect on the non …

Alterations of insulin signaling in diabetes are associated with podocyte injury, proteinuria,
and renal failure. Insulin stimulates glucose transport to cells and regulates other …

Objectives Exposure of podocytes to angiotensin II (Ang II) enhances the abundance of the
cell surface glycoprotein, low‐density lipoprotein receptor (LDLR) and promotes significant …

Mutations in the human INF2 gene cause autosomal dominant focal segmental
glomerulosclerosis (FSGS)—a condition characterized by podocyte loss, scarring, and …

Mutations in INF2 are associated with the complex symptoms of Charcot‐Marie‐Tooth
disease (CMT) and focal segmental glomerulosclerosis (FSGS). To date, more than 100 and …