NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers,
including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in …

In the ageing skeleton, the balance of bone reconstruction could commonly be broken by the
increasing of bone resorption and decreasing of bone formation. Consequently, the bone …

The treatment (ie therapy and management) of chronic lymphocytic leukemia (ie the
disease) has been improved thanks to the introduction (ie approval) of kinase inhibitors …

Signalling events downstream the B‐cell receptor (BCR) are central for the survival and
progression of chronic lymphocytic leukaemia (CLL) cells. Focal adhesion kinase (FAK) …

Cortactin is an actin-binding protein expressed in virtually all cell types. It regulates several
cell functions, including adhesion and migration. Cortactin overexpression is associated with …

Chronic lymphocytic leukemia (CLL) is a malignant clonal proliferative disorder of B cells.
Inhibition of cell apoptosis and cell cycle arrest are the main pathological causes of this …

Abstract Background and Aims: Previous investigations have revealed that microRNAs
(miRNAs) can function as oncogenes or tumor suppressors in chronic lymphocytic leukemia …

Background: Chronic lymphocytic leukemia (CLL) is the most common adult human
leukemia. Studies revealed that microRNAs (miRNAs) can function as oncogenes or tumor …

Cellular signaling is a fascinating phenomenon because of the scale of complexity involved
in it. Most proteins have to integrate inputs from multiple sources and generate an output …