Horizontal transfer of genomic islands (GEIs), that is, chromosomal regions encoding
functions that can be advantageous for the host, plays a key role in bacterial evolution, but …

For over seven decades, bacteria served as a valuable source of bioactive natural products
some of which were eventually developed into drugs to treat infections, cancer and immune …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Actinomycetes are one of the most valuable sources of natural products with industrial and
medicinal importance. After more than half a century of exploitation, it has become …

Covering: up to 2013The heterologous expression of microbial natural product biosynthetic
pathways coupled with advanced DNA engineering enables optimisation of product yields …

Production of secondary metabolites is a process influenced by several physico-chemical
factors including nutrient supply, oxygenation, temperature and pH. These factors have been …

Background Heterologous expression of secondary metabolite gene clusters is used to
achieve increased production of desired compounds, activate cryptic gene clusters …

Abstract Full-length RecE and RecT from Rac prophage mediate highly efficient linear–
linear homologous recombination that can be used to clone large DNA regions directly from …

Natural products discovery from actinomycetes has been on the decline in recent years, and
has suffered from a lack of innovative ways to discover new secondary metabolites within a …

Antimicrobial resistance genes (ARGs) and virulence factor genes (VFGs) constitute a
serious threat to public health, and climate change has been predicted to affect the increase …