Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

Curcumin, which was first used 3000 years ago as an anti-inflammatory agent, is a well-
known bioactive compound derived from the active ingredient of turmeric (Curcuma longa) …

Histone deacetylases are recently identified to act as key regulators for cardiac
pathophysiology and metabolic disorders. However, the function of histone deacetylase …

Diabetes increases the risk of heart failure approximately 2.5-fold, independent of coronary
artery disease and other comorbidities. This process, termed diabetic cardiomyopathy, is …

Covering: up to 2020 Chronic, low-grade inflammation is linked to aging and has been
termed “inflammaging”. Inflammaging is considered a key contributor to the development of …

Background Despite advances in the treatment of heart failure, mortality remains high,
particularly in individuals with diabetes. Activated transforming growth factor beta (TGF-β) …

Embryonic and postnatal life depend on the uninterrupted function of cardiac muscle cells.
These cells, termed cardiomyocytes, display many fascinating behaviors, including complex …

In living systems, the mechanisms of inheritance involving gene expression are operated by
(i) the traditional model of genetics where the deoxyribonucleic acid (DNA) transcription and …

Glomerulosclerosis and interstitial fibrosis represent the key events in development of
diabetic nephropathy (DN), with connective tissue growth factor (CTGF), plasminogen …

It has been extensively verified that inflammation and oxidative stress play important roles in
the pathogenesis of cardiovascular diseases (CVDs). Curcuminoids, from the plant Curcuma …