α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …

Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …

Extracellular α-synuclein is important in the pathogenesis of Parkinson's disease (PD) and
also as a potential biomarker when tested in the cerebrospinal fluid (CSF). The performance …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

In the 12 years since the publication of the first Consensus Paper of the WFSBP on
biomarkers of neurodegenerative dementias, enormous advancement has taken place in …

α-Synuclein is central in Parkinson's disease pathogenesis. Although initially α-synuclein
was considered a purely intracellular protein, recent data suggest that it can be detected in …

Since the discovery and isolation of α-synuclein (α-syn) from human brains, it has been
widely accepted that it exists as an intrinsically disordered monomeric protein. Two recent …

α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino
acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA …

Abnormal neuronal aggregation of α-synuclein is implicated in the development of many
neurological disorders, including Parkinson disease and dementia with Lewy bodies. Glial …

Exosomes are small membranous vesicles secreted by a number of cell types including
neurons and can be isolated from conditioned cell media or bodily fluids such as urine and …