Extracellular vesicles are produced by species across all domains of life, suggesting that
vesiculation represents a fundamental principle of living matter. In Gram-negative bacteria …

It has long been appreciated that the Gram-negative outer membrane acts as a permeability
barrier, but recent studies have uncovered a more expansive and versatile role for the outer …

Therapeutic mRNA vaccination is an attractive approach to trigger antitumor immunity.
However, the mRNA delivery technology for customized tumor vaccine is still limited. In this …

An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed.
Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are …

Recent advances in synthetic biology and materials science have given rise to a new form of
materials, namely engineered living materials (ELMs), which are composed of living matter …

The complex gastrointestinal environment and the intestinal epithelial barrier constrain the
design and effectiveness of orally administered tumour vaccines. Here we show that outer …

Secretion of cellular components across the plasma membrane is an essential process that
enables organisms to interact with their environments. Production of extracellular vesicles in …

Alzheimer's disease (AD) is a devastating age-related neurodegenerative disorder with an
alarming increasing prevalence. Except for the recently FDA-approved Aducanumab of …

The intestine is fundamental in controlling human health. Intestinal epithelial and immune
cells are continuously exposed to millions of microbes that greatly impact on intestinal …

Cancer vaccines based on resected tumors from patients have gained great interest as an
individualized cancer treatment strategy. However, eliciting a robust therapeutic effect with …