The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal
gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic …

Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

Free radicals generated within subcellular compartments damage macromolecules which
lead to severe structural changes and functional alterations of cellular organelles. A …

In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging
regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in …

Melatonin (MEL) has been revealed as a phylogenetically conserved molecule with a
ubiquitous distribution from primitive photosynthetic bacteria to higher plants, including …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …