Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

Obesity has become one of the most common medical problems in developed countries,
and this disorder is associated with high incidences of hypertension, dyslipidaemia …

Obesity is a serious public health issue and associated with an increased risk of
cardiovascular disease events and mortality. The risk of cardiovascular complications is …

Aging is associated with dysregulation of glucose and lipid metabolism. Various factors that
contribute to the dysregulation include both modifiable (eg obesity, insulin resistance) and …

GH is an important regulator of body growth and composition as well as numerous other
metabolic processes. In particular, liver plays a key role in the GH/IGF-I axis, because the …

Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays
an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to …

GH receptor (GHR) gene-disrupted mice (GHR−/−) have provided countless discoveries as
to the numerous actions of GH. Many of these discoveries highlight the importance of GH in …

OBJECTIVES: The mechanisms responsible for the development of nonalcoholic fatty liver
disease (NAFLD) and progression to nonalcoholic steatohepatitis (NASH) are incompletely …

In humans, low levels of growth hormone (GH) and its mediator, IGF-1, associate with
hepatic lipid accumulation. In mice, congenital liver-specific ablation of the GH receptor …

Cachexia associated with chronic kidney disease (CKD) has been linked to GH resistance.
In CKD, GH treatment enhances muscular performance. We investigated the impact of GH …