UV-induced DNA damage and repair: a review
Increases in ultraviolet radiation at the Earth's surface due to the depletion of the
stratospheric ozone layer have recently fuelled interest in the mechanisms of various effects …
stratospheric ozone layer have recently fuelled interest in the mechanisms of various effects …
Endogenous DNA damage in humans: a review of quantitative data
R De Bont, N Van Larebeke - Mutagenesis, 2004 - academic.oup.com
DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast
majority of mutations in human tissues are certainly of endogenous origin. A thorough …
majority of mutations in human tissues are certainly of endogenous origin. A thorough …
[图书][B] Casarett and Doull's toxicology: the basic science of poisons
CD Klaassen, MO Amdur - 2013 - researchgate.net
The question of what constitutes an acceptable risk is a matter of judgement. Such decisions
are multifaceted and complex, and involve a balance of risk and benefit. High risks may be …
are multifaceted and complex, and involve a balance of risk and benefit. High risks may be …
[HTML][HTML] Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of …
M Takata, MS Sasaki, E Sonoda, C Morrison… - The EMBO …, 1998 - embopress.org
Eukaryotic cells repair DNA double‐strand breaks (DSBs) by at least two pathways,
homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 …
homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 …
Homology-directed repair is a major double-strand break repair pathway in mammalian cells
F Liang, M Han, PJ Romanienko… - Proceedings of the …, 1998 - National Acad Sciences
Mammalian cells have been presumed to repair potentially lethal chromosomal double-
strand breaks (DSBs) in large part by processes that do not require homology to the break …
strand breaks (DSBs) in large part by processes that do not require homology to the break …
Digital logic circuits in yeast with CRISPR-dCas9 NOR gates
Natural genetic circuits enable cells to make sophisticated digital decisions. Building equally
complex synthetic circuits in eukaryotes remains difficult, however, because commonly used …
complex synthetic circuits in eukaryotes remains difficult, however, because commonly used …
Formation, prevention, and repair of DNA damage by iron/hydrogen peroxide
ES Henle, S Linn - Journal of Biological Chemistry, 1997 - ASBMB
Although oxygen is a powerful oxidant, the triplet ground state of dioxygen constitutes a
kinetic barrier for oxidation of biological molecules, which are mostly singlet state (1) …
kinetic barrier for oxidation of biological molecules, which are mostly singlet state (1) …
Role of the human RAD51 protein in homologous recombination and double-stranded-break repair
P Baumann, SC West - Trends in biochemical sciences, 1998 - cell.com
Eukaryotic cells possess several mechanisms for repairing double-stranded breaks in DNA.
One mechanism involves genetic recombination with an intact sister duplex. The recent …
One mechanism involves genetic recombination with an intact sister duplex. The recent …
[HTML][HTML] Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
E Sonoda, MS Sasaki, JM Buerstedde… - The EMBO …, 1998 - embopress.org
Yeast rad51 mutants are viable, but extremely sensitive to γ-rays due to defective repair of
double-strand breaks. In contrast, disruption of the murine RAD51 homologue is lethal …
double-strand breaks. In contrast, disruption of the murine RAD51 homologue is lethal …
Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations
P Pfeiffer, W Goedecke, G Obe - Mutagenesis, 2000 - academic.oup.com
DNA double-strand breaks (DSB) are considered to be critical primary lesions in the
formation of chromosomal aberrations. DSB may be induced by exogenous agents, such as …
formation of chromosomal aberrations. DSB may be induced by exogenous agents, such as …