Increases in ultraviolet radiation at the Earth's surface due to the depletion of the
stratospheric ozone layer have recently fuelled interest in the mechanisms of various effects …

DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast
majority of mutations in human tissues are certainly of endogenous origin. A thorough …

The question of what constitutes an acceptable risk is a matter of judgement. Such decisions
are multifaceted and complex, and involve a balance of risk and benefit. High risks may be …

Eukaryotic cells repair DNA double‐strand breaks (DSBs) by at least two pathways,
homologous recombination (HR) and non‐homologous end‐joining (NHEJ). Rad54 …

Mammalian cells have been presumed to repair potentially lethal chromosomal double-
strand breaks (DSBs) in large part by processes that do not require homology to the break …

Natural genetic circuits enable cells to make sophisticated digital decisions. Building equally
complex synthetic circuits in eukaryotes remains difficult, however, because commonly used …

Although oxygen is a powerful oxidant, the triplet ground state of dioxygen constitutes a
kinetic barrier for oxidation of biological molecules, which are mostly singlet state (1) …

Eukaryotic cells possess several mechanisms for repairing double-stranded breaks in DNA.
One mechanism involves genetic recombination with an intact sister duplex. The recent …

Yeast rad51 mutants are viable, but extremely sensitive to γ-rays due to defective repair of
double-strand breaks. In contrast, disruption of the murine RAD51 homologue is lethal …

DNA double-strand breaks (DSB) are considered to be critical primary lesions in the
formation of chromosomal aberrations. DSB may be induced by exogenous agents, such as …