Where are the disease-associated eQTLs?
Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …
have detectable effects on gene expression. One explanation could be that we have not …
Early developmental conditioning of later health and disease: physiology or pathophysiology?
MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …
environmental influences during early development affect the risk of later pathophysiological …
Detecting natural selection in genomic data
JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …
methods to identify genomic regions that appear to be shaped by natural selection. These …
Aging increases cell-to-cell transcriptional variability upon immune stimulation
Aging is characterized by progressive loss of physiological and cellular functions, but the
molecular basis of this decline remains unclear. We explored how aging affects …
molecular basis of this decline remains unclear. We explored how aging affects …
The evolution of gene expression in cis and trans
SA Signor, SV Nuzhdin - Trends in Genetics, 2018 - cell.com
There is abundant variation in gene expression between individuals, populations, and
species. The evolution of gene regulation and expression within and between species is …
species. The evolution of gene regulation and expression within and between species is …
[HTML][HTML] Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution
Enhanced cognitive function in humans is hypothesized to result from cortical expansion
and increased cellular diversity. However, the mechanisms that drive these phenotypic …
and increased cellular diversity. However, the mechanisms that drive these phenotypic …
Comparative transcriptomics in human and mouse
Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …
feasible at unprecedented resolution and throughput, enabling the comparison of human …
Interpretable factor models of single-cell RNA-seq via variational autoencoders
Motivation Single-cell RNA-seq makes possible the investigation of variability in gene
expression among cells, and dependence of variation on cell type. Statistical inference …
expression among cells, and dependence of variation on cell type. Statistical inference …
Detecting signatures of selection on gene expression
A substantial amount of phenotypic diversity results from changes in gene expression levels
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …
Gene regulatory network inference resources: A practical overview
D Mercatelli, L Scalambra, L Triboli, F Ray… - Biochimica et Biophysica …, 2020 - Elsevier
Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …