Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Structure, Function, and Pharmacology of NMDA Receptor Channels Page 1
PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2014 …

Polyamines, consisting of putrescine, spermidine and spermine are essential for normal cell
growth and viability in eukaryotic cells. Since polyamines are cations, they interact with DNA …

NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium
permeability that play important roles in many aspects of the biology of higher organisms …

N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors,
play key roles in normal brain development and various neurological disorders. Here we …

Abstract NMDA receptors (NMDARs), ligand-gated ion channels, play important roles in
various neurological disorders, including epilepsy. Here we show the functional analysis of …

N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …

Ionotropic glutamate receptors (iGluRs), including the NMDA receptor subtype, are ligand-
gated ion channels critical to fast signaling in the CNS. NMDA receptors are obligate …

NMDA receptors (NMDARs) are glutamate‐gated ion channels that contribute to nearly all
brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR …