Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

The potential existence and roles of the meningeal lymphatic system in normal and
pathological brain function have been a long-standing enigma. Recent evidence suggests …

Background Approximately 25% of the general population carries at least one ε4 allele of
the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer's …

In many populations, the a polipoprotein-ε 4 (APOE-ε 4) allele increases the risk for several
chronic diseases of aging, including dementia and cardiovascular disease; despite these …

Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation.
Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of …

Abstract Background The apolipoprotein E (APOE) ε4 allele confers higher risk of
neurodegeneration and Alzheimer's disease (AD), but differs by race/ethnicity. We examined …

Although APOE ε4 carriers are at substantially higher risk of developing Alzheimer's disease
than noncarriers, controversial evidence suggests that APOE ε4 might confer some …

In the last decade, extensive research has emerged into understanding the impact of risk
factors for Alzheimer's Disease (AD) on brain in pre-symptomatic stages. We investigated …

We explored the influence of child and maternal single nucleotide polymorphisms (SNPs) in
genes related to neurological function and arsenic metabolism (ie, ABCA1, ABCB1, PON1 …

Background: APOE 4 genotype was correlated with exacerbation of pathology and higher
risk of dementia in Parkinson's disease (PD). Meanwhile, the differential influence of APOE 4 …