The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid
leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease …

SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …

Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a family of RNA-binding
proteins. The complexity and diversity associated with the hnRNPs render them …

The oncogenic BCR/ABL kinase activity induces and maintains chronic myelogenous
leukemia (CML). We show here that, in BCR/ABL-transformed cells and CML blast crisis …

Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and
BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins …

Abstract hnRNP A1 is a nucleocytoplasmic shuttling protein that is involved in many aspects
of mRNA metabolism. We have previously shown that activation of the p38 stress-signaling …

Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

Proteins with motifs rich in arginines and glycines were discovered decades ago and are
functionally involved in a staggering range of essential processes in the cell. Versatile …

The eukaryotic translation initiation factor 4E (eIF4E) acts as both a key translation factor and
as a promoter of nucleocytoplasmic transport of specific transcripts. Traditionally, its …

The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is the most abundant and
ubiquitously expressed member of the heterogeneous nuclear ribonucleoproteins family …