Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

The blood-brain barrier (BBB) constitutes the interface between the blood and the brain
tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain …

Cells derived from pluripotent sources in vitro must resemble those found in vivo as closely
as possible at both transcriptional and functional levels in order to be a useful tool for …

ATP-binding cassette (ABC) transporters constitute one of the largest superfamilies of
conserved proteins from bacteria to mammals. In humans, three members of this family are …

Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for
many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis …

The pathological alterations that manifest during the early embryonic development due to
inherited and acquired factors trigger various neurodevelopmental disorders (NDDs) …

The blood–brain barrier (BBB) is a critical component of the central nervous system that
protects neurons and other cells of the brain parenchyma from potentially harmful …

The blood− brain barrier (BBB) is a unique vascular structure that serves as a molecular
transport gateway for the maintenance of brain homeostasis. Chronic disruption or …

Background Lipopolysaccharide (LPS) is one of the main constituents of the cell wall of
gram-negative bacteria. As an endotoxin, LPS induces neuroinflammation, which is …

The blood–brain barrier (BBB) plays an important role in brain homeostasis.
Hypoxia/ischemia constitutes an important stress factor involved in several neurological …