[HTML][HTML] The role and activity of SWI/SNF chromatin remodelers
T Bieluszewski, S Prakash, T Roulé… - Annual Review of Plant …, 2023 - annualreviews.org
SWITCH deficient SUCROSE NONFERMENTING (SWI/SNF) class chromatin remodeling
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …
Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles
Many membraneless organelles (MLOs) formed through phase separation play crucial roles
in various cellular processes. Although these MLOs co-exist in cells, how they maintain their …
in various cellular processes. Although these MLOs co-exist in cells, how they maintain their …
Cohesin regulates alternative splicing
AK Singh, Q Chen, C Nguyen, D Meerzaman… - Science …, 2023 - science.org
Cohesin, a trimeric complex that establishes sister chromatid cohesion, has additional roles
in chromatin organization and transcription. We report that among those roles is the …
in chromatin organization and transcription. We report that among those roles is the …
[HTML][HTML] DNA methylation episignature and comparative epigenomic profiling of HNRNPU-related neurodevelopmental disorder
K Rooney, L van der Laan, S Trajkova… - Genetics in …, 2023 - Elsevier
Purpose HNRNPU haploinsufficiency is associated with developmental and epileptic
encephalopathy 54. This neurodevelopmental disorder is characterized by developmental …
encephalopathy 54. This neurodevelopmental disorder is characterized by developmental …
Alpha‐synuclein promotes PRMT5‐mediated H4R3me2s histone methylation by interacting with the BAF complex
T Nakamura, N Sugeno, T Hasegawa… - The FEBS …, 2024 - Wiley Online Library
α‐Synuclein (αS) is a key molecule in the pathomechanism of Parkinson's disease. Most
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …
[HTML][HTML] SWI/SNF-dependent genes are defined by their chromatin landscape
L Basurto-Cayuela, JA Guerrero-Martínez… - Cell Reports, 2024 - cell.com
SWI/SNF complexes are evolutionarily conserved, ATP-dependent chromatin remodeling
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …
machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014 …
[HTML][HTML] Extensive Alternative Splicing Patterns in Systemic Lupus Erythematosus Highlight Sexual Differences
D Kosmara, S Papanikolaou, C Nikolaou, G Bertsias - Cells, 2023 - mdpi.com
Substantial evidence highlights divergences in immune responses between men and
women. Women are more susceptible to autoimmunity, whereas men suffer from the more …
women. Women are more susceptible to autoimmunity, whereas men suffer from the more …
Minor Spliceosomal 65K/RNPC3 Interacts with ANKRD11 and Mediates HDAC3‐Regulated Histone Deacetylation and Transcription
CH Li, SB Liang, QW Huang, ZZ Zhou, Z Ding… - Advanced …, 2024 - Wiley Online Library
RNA splicing is crucial in the multilayer regulatory networks for gene expression, making
functional interactions with DNA‐and other RNA‐processing machineries in the nucleus …
functional interactions with DNA‐and other RNA‐processing machineries in the nucleus …
[HTML][HTML] Elucidation of the Landscape of Alternatively Spliced Genes and Features in the Dorsal Striatum of Aggressive/Aggression-Deprived Mice in the Model of …
V Babenko, O Redina, D Smagin, I Kovalenko… - Genes, 2023 - mdpi.com
Both aggressive and aggression-deprived (AD) individuals represent pathological cases
extensively studied in psychiatry and substance abuse disciplines. We employed the animal …
extensively studied in psychiatry and substance abuse disciplines. We employed the animal …
Integrated multiomic profiling reveals SWI/SNF subunit-specific pathway alterations and targetable vulnerabilities
J Bretones-Santamarina, C Astier, M Garrido… - bioRxiv, 2024 - biorxiv.org
Mutations in subunits of the SWItch Sucrose Non-Fermentable (SWI/SNF) chromatin
remodeling complex occur in≈ 20% of cancers and represent a highly unmet medical need …
remodeling complex occur in≈ 20% of cancers and represent a highly unmet medical need …