Adaptive optics for high-resolution imaging

KM Hampson, R Turcotte, DT Miller… - Nature Reviews …, 2021 - nature.com
Adaptive optics (AO) is a technique that corrects for optical aberrations. It was originally
proposed to correct for the blurring effect of atmospheric turbulence on images in ground …

Regenerative and restorative medicine for eye disease

RN Van Gelder, MF Chiang, MA Dyer, TN Greenwell… - Nature medicine, 2022 - nature.com
Causes of blindness differ across the globe; in higher-income countries, most blindness
results from the degeneration of specific classes of cells in the retina, including retinal …

[HTML][HTML] Adaptive optics imaging of the human retina

SA Burns, AE Elsner, KA Sapoznik, RL Warner… - Progress in retinal and …, 2019 - Elsevier
Adaptive Optics (AO) retinal imaging has provided revolutionary tools to scientists and
clinicians for studying retinal structure and function in the living eye. From animal models to …

Inherited retinal degenerations: current landscape and knowledge gaps

JL Duncan, EA Pierce, AM Laster… - … vision science & …, 2018 - tvst.arvojournals.org
Inherited retinal degenerations (IRDs) represent a diverse group of progressive, visually
debilitating diseases that can lead to blindness in which mutations in genes that are critical …

Imaging and quantifying ganglion cells and other transparent neurons in the living human retina

Z Liu, K Kurokawa, F Zhang, JJ Lee… - Proceedings of the …, 2017 - National Acad Sciences
Ganglion cells (GCs) are fundamental to retinal neural circuitry, processing photoreceptor
signals for transmission to the brain via their axons. However, much remains unknown about …

Activated retinal pigment epithelium, an optical coherence tomography biomarker for progression in age-related macular degeneration

CA Curcio, EC Zanzottera, T Ach… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: To summarize and contextualize recent histology and clinical imaging publications
on retinal pigment epithelium (RPE) fate in advanced age-related macular degeneration …

Evolution of adaptive optics retinal imaging

DR Williams, SA Burns, DT Miller… - Biomedical Optics …, 2023 - opg.optica.org
This review describes the progress that has been achieved since adaptive optics (AO) was
incorporated into the ophthalmoscope a quarter of a century ago, transforming our ability to …

Twenty-five years of clinical applications using adaptive optics ophthalmoscopy

JIW Morgan, TYP Chui, K Grieve - Biomedical Optics Express, 2022 - opg.optica.org
Twenty-five years ago, adaptive optics (AO) was combined with fundus photography,
thereby initiating a new era in the field of ophthalmic imaging. Since that time, clinical …

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

JR Soucy, EA Aguzzi, J Cho, MJ Gilhooley… - Molecular …, 2023 - Springer
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

[HTML][HTML] Endpoints for clinical trials in ophthalmology

L Schmetterer, H Scholl, G Garhöfer… - Progress in Retinal and …, 2023 - Elsevier
With the identification of novel targets, the number of interventional clinical trials in
ophthalmology has increased. Visual acuity has for a long time been considered the gold …