Mechanisms of environmental contributions to fatty liver disease
Purpose Fatty liver disease (FLD) affects over 25% of the global population and may lead to
liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and …
liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and …
[HTML][HTML] Xenobiotic-induced aggravation of metabolic-associated fatty liver disease
J Massart, K Begriche, A Corlu, B Fromenty - International Journal of …, 2022 - mdpi.com
Metabolic-associated fatty liver disease (MAFLD), which is often linked to obesity,
encompasses a large spectrum of hepatic lesions, including simple fatty liver …
encompasses a large spectrum of hepatic lesions, including simple fatty liver …
Interaction of volatile organic compounds and underlying liver disease: a new paradigm for risk
Occupational and environmental exposures to industrial chemicals are known to cause
hepatotoxicity and liver injury, in humans and in animal models. Historically, research has …
hepatotoxicity and liver injury, in humans and in animal models. Historically, research has …
The effects of perfluorooctanoate on high fat diet induced non-alcoholic fatty liver disease in mice
Non-alcoholic fatty liver disease (NAFLD) is affecting up to one-third of the general
population in western countries. While the major cause of NAFLD is related to an unhealthy …
population in western countries. While the major cause of NAFLD is related to an unhealthy …
Integrating high-throughput phenotypic profiling and transcriptomic analyses to predict the hepatosteatosis effects induced by per-and polyfluoroalkyl substances
YS Luo, RY Ying, XT Chen, YJ Yeh, CC Wei… - Journal of Hazardous …, 2024 - Elsevier
Per-and polyfluoroalkyl substances (PFAS) is a large compound class (n> 12,000) that is
extensively present in food, drinking water, and aquatic environments. Reduced serum …
extensively present in food, drinking water, and aquatic environments. Reduced serum …
Role of xenobiotics in the induction and progression of fatty liver disease
Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans. Fatty
liver disease involves the accumulation of hepatocellular fat in hepatocytes that can …
liver disease involves the accumulation of hepatocellular fat in hepatocytes that can …
[HTML][HTML] Sub-chronic microcystin-LR liver toxicity in preexisting diet-induced nonalcoholic steatohepatitis in rats
T Arman, KD Lynch, ML Montonye, M Goedken… - Toxins, 2019 - mdpi.com
Microcystin-LR (MCLR) is a hepatotoxic cyanotoxin reported to cause a phenotype similar to
nonalcoholic steatohepatitis (NASH). NASH is a common progressive liver disease that …
nonalcoholic steatohepatitis (NASH). NASH is a common progressive liver disease that …
[HTML][HTML] MCLR-elicited hepatic fibrosis and carcinogenic gene expression changes persist in rats with diet-induced nonalcoholic steatohepatitis through a 4-week …
Nonalcoholic steatohepatitis (NASH) causes liver extracellular matrix (ECM) remodeling and
is a risk factor for fibrosis and hepatocellular carcinoma (HCC). Microcystin-LR (MCLR) is a …
is a risk factor for fibrosis and hepatocellular carcinoma (HCC). Microcystin-LR (MCLR) is a …
Using collaborative cross mouse population to fill data gaps in risk assessment: a case study of population-based analysis of toxicokinetics and kidney toxicodynamics …
Background: Interindividual variability in susceptibility remains poorly characterized for
environmental chemicals such as tetrachloroethylene (PERC). Development of population …
environmental chemicals such as tetrachloroethylene (PERC). Development of population …
Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity
Microcystin-LR (MCLR) is a cyanotoxin produced by blue-green algae that causes liver and
kidney toxicities. MCLR toxicity is dependent on cellular uptake through the organic anion …
kidney toxicities. MCLR toxicity is dependent on cellular uptake through the organic anion …