In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few
of these kinases are currently known to enable learning and memory. Based on this …

The age of an experimental animal can be a critical variable, yet age matters are often
overlooked within neuroscience. Many studies make use of young animals, without …

Anxiety disorders are commonly associated with increased generalization of fear from a
stress-or trauma-associated environment to a neutral context or environment. Differences in …

Hyperphosphorylation of the microtubule-associated protein tau is a characteristic feature of
neurodegenerative tauopathies including Alzheimer disease. Over-activation of proline …

This review will provide an overview of the non-drug based approaches that have been
demonstrated to enhance cognitive function of the compromised brain, primarily focussed on …

Abstract Cyclin‐dependent kinase 5 (Cdk5) is a serine/threonine kinase with a multitude of
functions. Although Cdk5 is widely expressed, it has been studied most extensively in …

Pain memories are hypothesized to be critically involved in the transition of pain from an
acute to a chronic state. To help elucidate the underlying neurobiological mechanisms of …

The structure of the mammalian hippocampus continues to be modified throughout life by
continuous addition of neurons in the dentate gyrus. Although the existence of adult …

Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Mutations in genes
encoding proteins involved in amyloid-β peptide (Aβ) production are responsible for …

Cyclin-dependent kinase 5 is activated by small subunits, of which p35 is the most
abundant. The functions of cyclin-dependent kinase 5 signalling in cognition and cognitive …