The orexin peptides (orexin A, orexin B) and their receptors (orexin receptor type 1, orexin
receptor type 2) are involved in multiple physiological processes such as the regulation of …

The hypothalamic neuropeptides orexin A and B (hypocretin 1 and 2) are important
homeostatic mediators of central control of energy metabolism and maintenance of …

The neuropeptides orexins and their G protein-coupled receptors, OX1 and OX2, were
discovered in 1998, and since then, their role has been investigated in many functions …

Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of
Alzheimer's disease (AD). Diets high in saturated fat potentiate the onset of obesity …

Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by
the hypothalamus. The main biological actions of orexins, focused on the central nervous …

Orexin A is produced in neurons of the lateral, perifornical and dorsomedial regions of the
lateral hypothalamic area, which then project widely throughout the central nervous system …

Orexin-A, a neuropeptide secreted by hypothalamic neurons, may be neuroprotective in
many neurological conditions such as cerebral ischaemia. One mechanism postulated to be …

The intranasal (IN) administration of neuropeptides, such as insulin and orexins, has been
suggested as a treatment strategy for age-related cognitive decline (ARCD). Because …

Excess dietary saturated fatty acids such as palmitic acid (PA) induce peripheral and
hypothalamic inflammation. Hypothalamic inflammation, mediated in part by microglial …

Poor quality and quantity of sleep are very common in elderly people throughout the world.
Growing evidence has suggested that sleep disturbances could accelerate the process of …