The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

The aim of this ESC Guideline is to help health professionals manage people with heart
failure (HF) according to the best available evidence. Fortunately, we now have a wealth of …

Abstract Document Reviewers: Rudolf A. de Boer (CPG Review Coordinator)(Netherlands),
P. Christian Schulze (CPG Review Coordinator)(Germany), Magdy Abdelhamid (Egypt) …

The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF)
continue to rise in tandem with the increasing age and burdens of obesity, sedentariness …

Left ventricular ejection fraction (EF) remains the major parameter for diagnosis,
phenotyping, prognosis and treatment decisions in heart failure. The 2016 ESC heart failure …

Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Heart failure with preserved ejection fraction (HFpEF) has grown to become the dominant
form of heart failure worldwide, in tandem with ageing of the general population and the …

In accordance with the comorbidity-inflammation paradigm, comorbidities and especially
metabolic comorbidities are presumed to drive development and severity of heart failure with …

Sedentary behavior and physical inactivity are among the leading modifiable risk factors
worldwide for cardiovascular disease and all-cause mortality. The promotion of physical …

Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …