The integration of most membrane proteins into the cytoplasmic membrane of bacteria
occurs co-translationally. The universally conserved YidC protein mediates this process …

Background Membrane proteins are underrepresented in structural databases, which has
led to a lack of computational tools and the corresponding inappropriate use of tools …

One of the unique traits of membrane proteins is that a significant fraction of their
hydrophobic amino acids is exposed to the hydrophobic core of lipid bilayers rather than …

The α-helical transmembrane proteins constitute 25% of the entire human proteome space
and are difficult targets in high-resolution wet-lab structural studies, calling for accurate …

Proteins are under selection to maintain central functions and to accommodate needs that
arise in ever‐changing environments. The positive selection and neutral drift that preserve …

Transmembrane protein (TMP) is an important type of membrane protein that is involved in
various biological membranes related biological processes. As major drug targets, TMPs' …

Solvent accessibility has been extensively used to characterize and predict the chemical
properties of the surface residues of soluble proteins. However, there is not yet a widely …

Prediction of the three-dimensional (3D) structures of proteins by computational methods is
acknowledged as an unsolved problem. Accurate prediction of important structural …

Transmembrane proteins (TMPs) play vital and diverse roles in many biological processes,
such as molecular transportation and immune response. Like other proteins, many major …

A protocol for predicting the hydrophobic length of membrane proteins using the
heterogeneous dielectric generalized Born (HDGB) implicit membrane model is presented …