Rationale and objectives: Repeated exposure to many drugs of abuse results in a
progressive and enduring enhancement in the motor stimulant effect elicited by a …

Behavioral sensitization refers to the progressive augmentation of behavioral responses to
psychomotor stimulants that develops during their repeated administration and persists even …

In animal models of drug addiction, cocaine exposure has been shown to increase levels of
calcium-permeable AMPA receptors (CP-AMPARs) in two brain regions that are critical for …

Behavioral sensitization to amphetamine involves the mesoaccumbens dopamine system
and is accompanied by cellular changes in this system. Excitatory amino acid antagonists …

It is well established that behavioral sensitization to psychomotor stimulants is associated
with adaptations in the mesoaccumbens dopamine (DA) system. We showed previously that …

This book provides a broad survey of many of the major areas in neuroplasticity research by
leading investigators in the field. The topics considered range across all levels of nervous …

Drug addiction is associated with long-lasting neuronal adaptations including alterations in
dopamine and glutamate receptors in the brain reward system. Treatment strategies for …

Previous electrophysiological studies suggested that the initiation of behavioral sensitization
to cocaine and amphetamine involves a transient increase in AMPA receptor …

Glutamate is critical for the induction and maintenance of behavioral sensitization and
associated neuroadaptations in the mesocorticolimbic dopamine (DA) system. We have …

Background Both psychostimulant use and engagement with probabilistic schedules of
reward sensitize the mesocorticolimbic dopamine (DA) system. Such behaviors may act …