Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …

Tendons and ligaments are crucial structures inside the musculoskeletal system. Still many
issues in the treatment of tendon diseases and injuries have yet not been resolved …

Despite clear evidence that exosomal microRNAs (miRNAs) are able to modulate the
cellular microenvironment and that exosomal RNA cargo selection is deregulated in …

PIWI-interacting small non-coding RNAs (piRNAs) are genetic and epigenetic regulatory
factors in germline cells, where they maintain genome stability, are involved in RNA …

Background Melanoma aggressiveness determines its growth and metastatic potential. This
study aimed at identifying new molecular pathways controlling melanoma cell malignancy …

Abstract MicroRNAs (miRNAs) are short (22 nucleotides), single-stranded, non-coding
RNAs that form complimentary base-pairs with the 3′ untranslated region of target mRNAs …

Breast cancer stem cells (BCSCs) play crucial roles in tumor initiation, metastasis and
therapeutic resistance. A strict dependency between BCSCs and stromal cell components of …

Harnessing the mechanisms underlying the exacerbated vascular remodeling in diabetes
mellitus (DM) is pivotal to prevent the high toll of vascular diseases in patients with DM …

Background The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-
silencing pathways It exerts a pivotal role in microRNA maturation and activity and can …

Much is known about estrogen action in experimental animal models and in human
physiology. This article reviews the mechanisms of estrogen activity in animals and humans …