ABSTRACT A vast array of oncogenic variants has been identified for anaplastic lymphoma
kinase (ALK). Therefore, there is a need to better understand the role of ALK in cancer …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …

Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

Recombination rate and linkage disequilibrium, the latter a function of population genomic
processes, are the critical parameters for mapping by linkage and association, and their …

Model organisms are of great importance to our understanding of basic biology and to
making advances in biomedical research. However, the influence of laboratory cultivation on …

The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the
development of the brain and can be oncogenically altered in several malignancies …

Although many studies have examined quantitative trait variation across many species, only
a small number of genes and thereby molecular mechanisms have been discovered …

Transforming Growth Factor-β (TGF-β) superfamily ligands regulate many aspects of cell
identity, function, and survival in multicellular animals. Genes encoding five TGF-β family …