Regenerative medicine harnesses the body's innate capacity for self-repair to restore
malfunctioning tissues and organs. Stem cell therapies represent a key regenerative …

Simple Summary Wnt signaling is one of the main evolutionarily conserved developmental
pathways needed to instruct embryo formation and maintenance of organ tissues. Decades …

The evolutionary trajectory of glioblastoma (GBM) is a multifaceted biological process that
extends beyond genetic alterations alone. Here, we perform an integrative proteogenomic …

In the last decades, important progress has been achieved in the understanding of the
neurotrophic effects of intermittent fasting (IF), calorie restriction (CR) and exercise …

Glioblastoma (GB) is one of the most adverse diagnoses in oncology. Complex current
treatment results in a median survival of 15 months. Resistance to treatment is associated …

Purpose We established the genetic etiology of a syndromic neurodevelopmental condition
characterized by variable cognitive impairment, recognizable facial dysmorphism, and a …

Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by
mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism …

Highly prevalent in laboratory rodents,'social'hetero-grooming behavior is translationally
relevant to modeling a wide range of neuropsychiatric disorders. Here, we comprehensively …

Neurodegenerative diseases (NDs) are conditions characterized by sensory, motor, and
cognitive impairments due to alterations in the structure and function of neurons in the …

Adult hippocampal neurogenesis (AHN) is associated with hippocampus-dependent
cognitive function, and its initiation is attributed to neural stem cells (NSCs). Dysregulated …