Conserved and divergent mechanisms of inner kinetochore assembly onto centromeric chromatin
Kinetochores are large protein complexes built on centromeric chromatin that mediate
chromosome segregation. The inner kinetochore, or constitutive centromere-associated …
chromosome segregation. The inner kinetochore, or constitutive centromere-associated …
Kinetochore architecture employs diverse linker strategies across evolution
S Sridhar, T Fukagawa - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The assembly of a functional kinetochore on centromeric chromatin is necessary to connect
chromosomes to the mitotic spindle, ensuring accurate chromosome segregation. This …
chromosomes to the mitotic spindle, ensuring accurate chromosome segregation. This …
Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere
The point centromere of budding yeast specifies assembly of the large kinetochore complex
to mediate chromatid segregation. Kinetochores comprise the centromere-associated inner …
to mediate chromatid segregation. Kinetochores comprise the centromere-associated inner …
Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
R Pleuger, C Cozma, S Hohoff, C Denkhaus… - Current Biology, 2024 - cell.com
Faithful chromosome segregation requires that sister chromatids establish bi-oriented
kinetochore-microtubule attachments. The spindle assembly checkpoint (SAC) prevents …
kinetochore-microtubule attachments. The spindle assembly checkpoint (SAC) prevents …
Structural mechanism of outer kinetochore Dam1-Ndc80 complex assembly on microtubules
Kinetochores couple chromosomes to the mitotic spindle to segregate the genome during
cell division. An error correction mechanism drives the turnover of kinetochore-microtubule …
cell division. An error correction mechanism drives the turnover of kinetochore-microtubule …
[PDF][PDF] 核孔复合物单分子定位超分辨图像的筛选和重构
侯梦迪， 胡芬， 杨建宇， 董浩， 潘雷霆 - 中国激光, 2024 - researching.cn
摘要核孔复合物(NPC) 是细胞核膜上由多种蛋白组装而成的复杂结构, 在细胞核质交换和信息
传递中起着关键作用. 单分子定位超分辨成像(SMLM) 以其特异性和高成像分辨率成为研究NPC …
传递中起着关键作用. 单分子定位超分辨成像(SMLM) 以其特异性和高成像分辨率成为研究NPC …
Kinetochore–microtubule error correction for biorientation: lessons from yeast
S Li, T Kasciukovic, TU Tanaka - Biochemical Society …, 2024 - portlandpress.com
Accurate chromosome segregation in mitosis relies on sister kinetochores forming stable
attachments to microtubules (MTs) extending from opposite spindle poles and establishing …
attachments to microtubules (MTs) extending from opposite spindle poles and establishing …
Build and operation of a custom 3D, multicolor, single-molecule localization microscope
Single-molecule localization microscopy (SMLM) enables imaging scientists to visualize
biological structures with unprecedented resolution. Particularly powerful implementations of …
biological structures with unprecedented resolution. Particularly powerful implementations of …
Mechanism of outer kinetochore assembly on microtubules and its regulation by mitotic error correction
Kinetochores couple chromosomes to the mitotic spindle and transduce the energy of
microtubule depolymerization to segregate the genome during cell division. Kinetochore …
microtubule depolymerization to segregate the genome during cell division. Kinetochore …
Automated 3D multi-color single-molecule localization microscopy
Since its inception, single molecule localization microscopy (SMLM) has enabled imaging
scientists to visualize biological structures with unprecedented resolution. Particularly …
scientists to visualize biological structures with unprecedented resolution. Particularly …