[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Approaches for enhancing oral bioavailability of peptides and proteins

J Renukuntla, AD Vadlapudi, A Patel… - International journal of …, 2013 - Elsevier
Oral delivery of peptide and protein drugs faces immense challenge partially due to the
gastrointestinal (GI) environment. In spite of considerable efforts by industrial and academic …

[HTML][HTML] A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives

A Muheem, F Shakeel, MA Jahangir, M Anwar… - Saudi Pharmaceutical …, 2016 - Elsevier
In the modern world, a number of therapeutic proteins such as vaccines, antigens, and
hormones are being developed utilizing different sophisticated biotechnological techniques …

Novel delivery approaches for cancer therapeutics

AK Mitra, V Agrahari, A Mandal, K Cholkar… - Journal of controlled …, 2015 - Elsevier
Currently, a majority of cancer treatment strategies are based on the removal of tumor mass
mainly by surgery. Chemical and physical treatments such as chemo-and radiotherapies …

Novel strategies for anterior segment ocular drug delivery

K Cholkar, SP Patel, AD Vadlapudi… - Journal of ocular …, 2013 - liebertpub.com
Research advancements in pharmaceutical sciences have led to the development of new
strategies in drug delivery to anterior segment. Designing a new delivery system that can …

Transporter-mediated drug delivery

G Gyimesi, MA Hediger - Molecules, 2023 - mdpi.com
Transmembrane transport of small organic and inorganic molecules is one of the
cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier …

Solid lipid matrix mediated nanoarchitectonics for improved oral bioavailability of drugs

S Banerjee, J Pillai - Expert opinion on drug metabolism & …, 2019 - Taylor & Francis
Introduction: Solid matrix mediated lipid nanoparticle formulations (LNFs) retain some of the
best features of ideal drug carriers necessary for improving the oral absorption and …

Physicochemical characterization techniques for solid lipid nanoparticles: principles and limitations

N Kathe, B Henriksen, H Chauhan - Drug development and …, 2014 - Taylor & Francis
Solid lipid nanoparticles (SLNs) are gaining importance due to numerous advantages they
offer as a drug delivery system. SLN incorporate poorly soluble drugs, proteins, biologicals …

Nano lipid-drug conjugate: An integrated review

P Adhikari, P Pal, AK Das, S Ray… - International journal of …, 2017 - Elsevier
Abstract Lipid-drug conjugates (LDC), which may also be addressed as lipoidal prodrug,
have the therapeutic actives chemically bound to a lipid moiety like fatty acids or …

Ocular drug delivery

B Yavuz, UB Kompella - Pharmacologic Therapy of Ocular Disease, 2017 - Springer
Although the eye is an accessible organ for direct drug application, ocular drug delivery
remains a major challenge due to multiple barriers within the eye. Key barriers include static …