The progress in understanding and treatment of diabetic retinopathy

AW Stitt, TM Curtis, M Chen, RJ Medina… - Progress in retinal and …, 2016 - Elsevier
Diabetic retinopathy is the most frequently occurring complication of diabetes mellitus and
remains a leading cause of vision loss globally. Its aetiology and pathology have been …

Molecular pathogenesis of retinal and choroidal vascular diseases

PA Campochiaro - Progress in retinal and eye research, 2015 - Elsevier
There are two major types of ocular neovascularization that affect the retina, retinal
neovascularization (NV) and subretinal or choroidal NV. Retinal NV occurs in a group of …

Intravitreal aflibercept for diabetic macular edema

JF Korobelnik, DV Do, U Schmidt-Erfurth, DS Boyer… - Ophthalmology, 2014 - Elsevier
Purpose A head-to-head comparison was performed between vascular endothelial growth
factor blockade and laser for treatment of diabetic macular edema (DME). Design Two …

[HTML][HTML] Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE

DM Brown, QD Nguyen, DM Marcus, DS Boyer, S Patel… - Ophthalmology, 2013 - Elsevier
Purpose To report 36-month outcomes of RIDE (NCT00473382) and RISE (NCT00473330),
trials of ranibizumab in diabetic macular edema (DME). Design Phase III, randomized …

Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE

QD Nguyen, DM Brown, DM Marcus, DS Boyer, S Patel… - Ophthalmology, 2012 - Elsevier
PURPOSE: To evaluate the efficacy and safety of intravitreal ranibizumab in diabetic
macular edema (DME) patients. DESIGN: Two parallel, methodologically identical, phase III …

[HTML][HTML] Ocular complications of diabetes mellitus

N Sayin, N Kara, G Pekel - World journal of diabetes, 2015 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a important health problem that induces ernestful complications
and it causes significant morbidity owing to specific microvascular complications such as …

Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema

MJ Elman, LP Aiello, RW Beck, NM Bressler… - Ophthalmology, 2010 - Elsevier
OBJECTIVE: Evaluate intravitreal 0.5 mg ranibizumab or 4 mg triamcinolone combined with
focal/grid laser compared with focal/grid laser alone for treatment of diabetic macular edema …

Safety and Efficacy of Ranibizumab in Diabetic Macular Edema (RESOLVE Study) A 12-month, randomized, controlled, double-masked, multicenter phase II study

P Massin, F Bandello, JG Garweg, LL Hansen… - Diabetes …, 2010 - Am Diabetes Assoc
OBJECTIVE The expression of vascular endothelial growth factor (VEGF) is elevated in
diabetic macular edema (DME). Ranibizumab binds to and inhibits multiple VEGF variants …

Anti‐vascular endothelial growth factor for diabetic macular oedema

G Virgili, M Parravano, F Menchini… - Cochrane Database of …, 2014 - cochranelibrary.com
Background Diabetic macular oedema (DMO) is a common complication of diabetic
retinopathy. Although grid or focal laser photocoagulation has been shown to reduce the risk …

Clinical pharmacology of intravitreal anti-VEGF drugs

S Fogli, M Del Re, E Rofi, C Posarelli, M Figus… - Eye, 2018 - nature.com
Clinical efficacy of intravitreal anti-VEGF drugs has been widely demonstrated in several
angiogenesis-driven eye diseases including diabetic macular edema and the neovascular …