Metagenomics: the next culture-independent game changer

JD Forbes, NC Knox, J Ronholm, F Pagotto… - Frontiers in …, 2017 - frontiersin.org
A trend towards the abandonment of obtaining pure culture isolates in frontline laboratories
is at a crossroads with the ability of public health agencies to perform their basic mandate of …

[PDF][PDF] Panels and syndromic testing in clinical microbiology

JD Bard, E McElvania - Clinics in laboratory medicine, 2020 - Elsevier
Syndromic panels have allowed clinical microbiology laboratories to rapidly identify
bacteria, viruses, fungi, and parasites and are now fully integrated into many clinical …

Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study

J Liu, JA Platts-Mills, J Juma, F Kabir, J Nkeze, C Okoi… - The Lancet, 2016 - thelancet.com
Background Diarrhoea is the second leading cause of mortality in children worldwide, but
establishing the cause can be complicated by diverse diagnostic approaches and varying …

Multiplexed molecular diagnostics for respiratory, gastrointestinal, and central nervous system infections

KE Hanson, MR Couturier - Clinical Infectious Diseases, 2016 - academic.oup.com
abstract The development and implementation of highly multiplexed molecular diagnostic
tests have allowed clinical microbiology laboratories to more rapidly and sensitively detect a …

Why antibiotics should not be used to treat Shiga toxin-producing Escherichia coli infections

PI Tarr, SB Freedman - Current opinion in gastroenterology, 2022 - journals.lww.com
In high-income countries, antibiotics should not routinely be given to patients with acute
diarrhea unless testing demonstrates a pathogen for which antibiotics are indicated, and …

Ten years of R&D and full automation in molecular diagnosis

G Greub, R Sahli, R Brouillet, K Jaton - Future microbiology, 2016 - Taylor & Francis
A 10-year experience of our automated molecular diagnostic platform that carries out 91
different real-time PCR is described. Progresses and future perspectives in molecular …

Multicenter evaluation of BD Max enteric parasite real-time PCR assay for detection of Giardia duodenalis, Cryptosporidium hominis, Cryptosporidium parvum, and …

S Madison-Antenucci, RF Relich, L Doyle… - Journal of clinical …, 2016 - Am Soc Microbiol
Common causes of chronic diarrhea among travelers worldwide include protozoan
parasites. The majority of parasitic infections are caused by Giardia duodenalis, Entamoeba …

A method for detection of SARS-CoV-2 RNA in healthy human stool: a validation study

MP Coryell, M Iakiviak, N Pereira, PP Murugkar… - The Lancet …, 2021 - thelancet.com
Background Faecal shedding of SARS-CoV-2 has raised concerns about transmission
through faecal microbiota transplantation procedures. Validation parameters of authorised …

The GenMark ePlex®: another weapon in the syndromic arsenal for infection diagnosis

JE Schmitz, YW Tang - Future microbiology, 2018 - Taylor & Francis
As one of the most recent additions to the syndromic testing landscape, the ePlex® platform
by GenMark Diagnostics is a system that combines the manufacturer's signature …

Integrated LAMP and immunoassay platform for diarrheal disease detection

CR Phaneuf, B Mangadu, HM Tran, YK Light… - Biosensors and …, 2018 - Elsevier
The challenges of diagnosing infectious disease, especially in the developing world, and the
shortcomings of available instrumentation have exposed the need for portable, easy-to-use …