Microglia, the immunocompetent cells in the central nervous system (CNS), have long been
studied as pathologically deteriorating players in various CNS diseases. However, microglia …

Chronic and neuropathic pain are a widespread burden. Incomplete understanding of
underlying pathomechanisms is one crucial factor for insufficient treatment. Recently …

Background The purpose of this study was to evaluate the effect of dexamethasone or
dexmedetomidine added to ropivacaine on the onset and duration of ultrasound-guided …

Spinal cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent
generation of spontaneous action potentials (SA) in peripheral branches and the somata of …

Background: Dexmedetomidine (Dexm), a selective alpha-2 adrenoceptor agonist, and
dexamethasone (Dexa), a very potent and highly selective glucocorticoid, have both been …

Background: It is necessary to understand the mechanism of trigeminal neuralgia (TN) and
hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous …

Study objective Caudal block helps relieve pain after sub-umbilical surgery in pediatric
patients; however, the duration for which it exerts its analgesic effect is limited. The addition …

It has been well documented that Wallerian degeneration following nerve injury is
associated with inflammatory reaction. Such local inflammation contributes to the …

This paper demonstrates a polyimide nerve cuff electrode with a controllable drug
loading/release function for stable recording of peripheral nerve signals and stimulation and …

The multicomponent etiology, complex clinical implications, dose-based side effect and
degree of pain mitigation associated with the current pharmacological therapy is incapable …