The reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive and compulsive behaviors
K Blum, ER Braverman, JM Holder… - … of psychoactive drugs, 2000 - Taylor & Francis
The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated
in reward mechanisms. The net effect of neurotransmitter interaction at the mesolimbic brain …
in reward mechanisms. The net effect of neurotransmitter interaction at the mesolimbic brain …
A novel strategy for the treatment of cocaine addiction
SL Dewey, AE Morgan, CR Ashby Jr, B Horan… - Synapse, 1998 - Wiley Online Library
Cocaine's addictive liability has been linked to its pharmacologic actions on
mesotelencephalic dopamine (DA) reinforcement/reward pathways in the central nervous …
mesotelencephalic dopamine (DA) reinforcement/reward pathways in the central nervous …
Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter
NT Bello, KL Sweigart, JM Lakoski… - American journal …, 2003 - journals.physiology.org
Recent studies suggest that the mesoaccumbens dopamine system undergoes
neurochemical alterations as a result of restricted feeding conditions with access to sugars …
neurochemical alterations as a result of restricted feeding conditions with access to sugars …
Repeated access to sucrose augments dopamine turnover in the nucleus accumbens
A Hajnal, R Norgren - Neuroreport, 2002 - journals.lww.com
Dopamine in the nucleus accumbens has been implicated in motivated behavior, including
feeding. Normal feeding occurs in patterns, but little is known about how these schedules …
feeding. Normal feeding occurs in patterns, but little is known about how these schedules …
Increased mesolimbic GABA concentration blocks heroin self-administration in the rat
Opiate reinforcement has been hypothesized to be mediated by an inhibition of mesolimbic
γ-aminobutyric acid (GABA) release that subsequently disinhibits ventral tegmental area …
γ-aminobutyric acid (GABA) release that subsequently disinhibits ventral tegmental area …
Effects of pharmacologic increases in brain GABA levels on cocaine‐induced changes in extracellular dopamine
AE Morgan, SL Dewey - Synapse, 1998 - Wiley Online Library
Cocaine‐induced increases in extracellular dopamine (DA) concentrations were measured
using in vivo microdialysis techniques in the nucleus accumbens (NACC) of freely moving …
using in vivo microdialysis techniques in the nucleus accumbens (NACC) of freely moving …
Cocaine‐induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta‐analysis
ST Frank, B Krumm, R Spanagel - Synapse, 2008 - Wiley Online Library
A meta‐analysis was conducted on data obtained from published articles which used in vivo
microdialysis to assess dose‐response curves of cocaine on dopamine (DA) overflow within …
microdialysis to assess dose‐response curves of cocaine on dopamine (DA) overflow within …
In VivoElectrochemical Studies of Dopamine Clearance in Subregions of Rat Nucleus Accumbens: Differential Properties of the Core and Shell
DJ David, NR Zahniser, BJ Hoffer, GA Gerhardt - Experimental neurology, 1998 - Elsevier
The dopamine (DA) uptake/clearance properties of the DA transporter (DAT) in the core and
shell of the nucleus accumbens were measured usingin vivoelectrochemical recordings …
shell of the nucleus accumbens were measured usingin vivoelectrochemical recordings …
[HTML][HTML] Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference
K Felszeghy, JM Espinosa, H Scarna, A Bérod… - …, 2007 - nature.com
Chronic use of psychostimulants induces enduringly increased responsiveness to a
subsequent psychostimulant injection and sensitivity to drug-associated cues, contributing to …
subsequent psychostimulant injection and sensitivity to drug-associated cues, contributing to …
γ-Aminobutyric acid mimetic drugs differentially inhibit the dopaminergic response to cocaine
MR Gerasimov, WK Schiffer, JD Brodie… - European journal of …, 2000 - Elsevier
Dopaminergic activity in the mesocorticolimbic system is associated with reinforcing
properties of psychostimulant drugs. We previously demonstrated that increased γ …
properties of psychostimulant drugs. We previously demonstrated that increased γ …