Background Nicotine replacement therapy (NRT) aims to replace nicotine from cigarettes to
ease the transition from cigarette smoking to abstinence. It works by reducing the intensity of …

This review gives an account of the cigarette as a highly efficient nicotine delivery system. It
explains how nicotine induces pleasure, reduces stress and anxiety, and causes addiction …

Background Nicotine replacement therapy (NRT) aims to temporarily replace much of the
nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms …

Nicotine underlies tobacco addiction, influences tobacco use patterns, and is used as a
pharmacological aid to smoking cessation. The absorption, distribution and disposition …

Nicotine sustains tobacco addiction, a major cause of disability and premature death.
Nicotine binds to nicotinic cholinergic receptors, facilitating neurotransmitter release and …

Understanding the basic and clinical pharmacology of nicotine provides a basis for
improved prevention and treatment of tobacco addiction. Nicotine acts on nicotinic …

Background Most people who stop smoking gain weight. This can discourage some people
from making a quit attempt and risks offsetting some, but not all, of the health advantages of …

Substance and alcohol use disorders impose large health and economic burdens on
individuals, families, communities, and society. Neither prevention nor treatment efforts are …

Background Substantial variability exists in therapeutic response and adverse effects with
pharmacotherapies for tobacco dependence. Biomarkers to optimise treatment choice for …

The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant
substrates, including nicotine—the primary psychoactive component in cigarette smoke. The …