Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …

Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …

Obesity is a new risk factor, to which more and more research is devoted, related to the
development of cancer. Many studies of recent years have drawn attention to the role of …

Leptin is an obesity-associated adipokine that is known to regulate energy metabolism and
reproduction and to control appetite via the leptin receptor. Recent work has identified …

Despite the proven tumorigenic effect of leptin on epithelial-derived cancers, its impact on
the aggressiveness of neural crest-derived cancers, notably neuroblastoma, remains largely …

Leptin is a peptide hormone that has been characterized as the ligand of leptin receptor
(LEPR). The observation of leptin secretion and leptin receptor expression beyond the …

Purpose: Gliomas are the most common primary malignant neoplasms of the central
nervous system. Secreted phospholipases A2 (sPLA2s) are known to play an important role …

Simple Summary Despite recent advances in molecular brain tumor therapies, glioblastoma
multiforme remains a diagnostic and therapeutic challenge with, in most cases, unfavorable …

Background: Glucagon-like peptide-2 (GLP-2) is an intestinal trophic factor that induces
astrocyte proliferation through its own receptor (GLP-2R), but the control of its expression is …