Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Cross-linking mass spectrometry (XL-MS) has matured into a potent tool to identify protein–
protein interactions or to uncover protein structures in living cells, tissues, or organelles. The …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

The majority of processes that occur in daily cell life are modulated by hundreds to
thousands of dynamic protein–protein interactions (PPI). The resulting protein complexes …

Crosslinking mass spectrometry (XL-MS) is a valuable technique for generating point-to-
point distance measurements in protein space. However, cell-based XL-MS experiments …

Various protein cross‐linking reactions leading to molecular polymerization and covalent
aggregates have been described in processed foods. They are an undesired side effect of …

Improving the sensitivity of protein–protein interaction detection and protein structure
probing is a principal challenge in cross-linking mass spectrometry (XL-MS) data analysis. In …

Background Cross-linking mass spectrometry (XL-MS) is a powerful technique for detecting
protein–protein interactions (PPIs) and modeling protein structures in a high-throughput …

Cross-linking MS (XL-MS) has been recognized as an effective source of information about
protein structures and interactions. In contrast to regular peptide identification, XL-MS has to …

When it comes to mass spectrometry data analysis for identification of peptide pairs linked
by N-hydroxysuccinimide (NHS) ester cross-linkers, search engines bifurcate in their setting …