Cells are the fundamental units of life, and like all life forms, they change over time. Changes
in cell state are driven by molecular processes; of these many are initiated when molecule …

Action potential (AP)-triggered neurotransmitter release forms the key basis of inter-neuronal
communication. We present a stochastic hybrid system model that captures the release of …

The timing of cellular events is often determined by the instant when the level of a chemical
species crosses a threshold from an initial value of zero. To attenuate the inherent random …

Many intracellular events trigger upon attaining critical concentrations of their corresponding
regulatory proteins. How cells ensure precision in the timing of these events is a …

The timing of biochemical events is often determined by the accumulation of a protein or
chemical species to a critical threshold level. In a stochastic model, we define event timing …

The timing of diverse cellular processes is based on the instant when the concentration of
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …

One of the most difficult and pressing problems in computational cell biology is the inference
of gene regulatory network structure from transcriptomic data. Benchmarking network …

Action potential (AP)-triggered neurotransmitter release forms the key basis of inter-neuronal
communication. We present a stochastic hybrid system model that captures the release of …

Within cells, transcription factors (TFs) bind to a wide range of nonspecific genomic sites in
addition to their target sites. Binding to such high affinity “decoys” has been shown to …

The timing of diverse cellular processes is based on the instant when the concentration of
regulatory proteins crosses a critical threshold level. Hence, noise mechanisms inherent to …