The physiology of bilirubin: health and disease equilibrium
L Vitek, TD Hinds, DE Stec, C Tiribelli - Trends in molecular medicine, 2023 - cell.com
Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …
Bilirubin as a metabolic hormone: the physiological relevance of low levels
JF Creeden, DM Gordon, DE Stec… - American Journal of …, 2021 - journals.physiology.org
Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …
suggests an entirely new function as a metabolic hormone that drives gene transcription by …
Reactive oxygen species (ROS) and antioxidants as immunomodulators in exercise: implications for heme oxygenase and bilirubin
DT Thomas, NR DelCimmuto, KD Flack, DE Stec… - Antioxidants, 2022 - mdpi.com
Exercise is commonly prescribed as a lifestyle treatment for chronic metabolic diseases as it
functions as an insulin sensitizer, cardio-protectant, and essential lifestyle tool for effective …
functions as an insulin sensitizer, cardio-protectant, and essential lifestyle tool for effective …
Bilirubin levels are negatively correlated with adiposity in obese men and women, and its catabolized product, urobilin, is positively associated with insulin resistance
Bilirubin levels in obese humans and rodents have been shown to be lower than in their
lean counterparts. Some studies have proposed that the glucuronyl UGT1A1 enzyme that …
lean counterparts. Some studies have proposed that the glucuronyl UGT1A1 enzyme that …
Induction of mild hyperbilirubinemia: hype or real therapeutic opportunity?
L Vitek, C Bellarosa, C Tiribelli - Clinical Pharmacology & …, 2019 - Wiley Online Library
Observational epidemiological studies showed that mild hyperbilirubinemia has beneficial
effects on the prevention of cardiovascular disease, type 2 diabetes mellitus, and metabolic …
effects on the prevention of cardiovascular disease, type 2 diabetes mellitus, and metabolic …
In vivo toxicity of copper oxide, lead oxide and zinc oxide nanoparticles acting in different combinations and its attenuation with a complex of innocuous bio-protectors
IA Minigalieva, BA Katsnelson, VG Panov, LI Privalova… - Toxicology, 2017 - Elsevier
Stable suspensions of metal oxide nanoparticles (Me-NPs) obtained by laser ablation of
99.99% pure copper, zinc or lead under a layer of deionized water were used separately, in …
99.99% pure copper, zinc or lead under a layer of deionized water were used separately, in …
Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations
Objective To determine response rates for clinically significant weight loss (CWL) following
different aerobic exercise training amounts and whether enhanced cardiometabolic …
different aerobic exercise training amounts and whether enhanced cardiometabolic …
Serum bilirubin concentrations and the prevalence of Gilbert syndrome in elite athletes
J Woronyczová, M Nováková, M Leníček… - Sports Medicine …, 2022 - Springer
Objectives Bilirubin is a potent endogenous antioxidant and immunomodulating substance,
which is also implicated in both cell signalling and various metabolic pathways. Mild …
which is also implicated in both cell signalling and various metabolic pathways. Mild …
Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells
SO Adeosun, DM Gordon, MF Weeks… - American Journal …, 2018 - journals.physiology.org
Obesity and increased lipid availability have been implicated in the development and
progression of chronic kidney disease. One of the major sites of renal lipid accumulation is …
progression of chronic kidney disease. One of the major sites of renal lipid accumulation is …
Bilirubin as a predictor of diseases of civilization. Is it time to establish decision limits for serum bilirubin concentrations?
L Vitek - Archives of biochemistry and biophysics, 2019 - Elsevier
Bilirubin is among the most potent of the endogenous antioxidants. Data developed over the
last three decades have convincingly demonstrated the protective effects of mildly elevated …
last three decades have convincingly demonstrated the protective effects of mildly elevated …