The physiology of bilirubin: health and disease equilibrium

L Vitek, TD Hinds, DE Stec, C Tiribelli - Trends in molecular medicine, 2023 - cell.com
Bilirubin has several physiological functions, both beneficial and harmful. In addition to
reactive oxygen species-scavenging activities, bilirubin has potent immunosuppressive …

Bilirubin as a metabolic hormone: the physiological relevance of low levels

JF Creeden, DM Gordon, DE Stec… - American Journal of …, 2021 - journals.physiology.org
Recent research on bilirubin, a historically well-known waste product of heme catabolism,
suggests an entirely new function as a metabolic hormone that drives gene transcription by …

Reactive oxygen species (ROS) and antioxidants as immunomodulators in exercise: implications for heme oxygenase and bilirubin

DT Thomas, NR DelCimmuto, KD Flack, DE Stec… - Antioxidants, 2022 - mdpi.com
Exercise is commonly prescribed as a lifestyle treatment for chronic metabolic diseases as it
functions as an insulin sensitizer, cardio-protectant, and essential lifestyle tool for effective …

Bilirubin levels are negatively correlated with adiposity in obese men and women, and its catabolized product, urobilin, is positively associated with insulin resistance

ZA Kipp, M Xu, EA Bates, WH Lee, PA Kern… - Antioxidants, 2023 - mdpi.com
Bilirubin levels in obese humans and rodents have been shown to be lower than in their
lean counterparts. Some studies have proposed that the glucuronyl UGT1A1 enzyme that …

Induction of mild hyperbilirubinemia: hype or real therapeutic opportunity?

L Vitek, C Bellarosa, C Tiribelli - Clinical Pharmacology & …, 2019 - Wiley Online Library
Observational epidemiological studies showed that mild hyperbilirubinemia has beneficial
effects on the prevention of cardiovascular disease, type 2 diabetes mellitus, and metabolic …

In vivo toxicity of copper oxide, lead oxide and zinc oxide nanoparticles acting in different combinations and its attenuation with a complex of innocuous bio-protectors

IA Minigalieva, BA Katsnelson, VG Panov, LI Privalova… - Toxicology, 2017 - Elsevier
Stable suspensions of metal oxide nanoparticles (Me-NPs) obtained by laser ablation of
99.99% pure copper, zinc or lead under a layer of deionized water were used separately, in …

Effects of clinically significant weight loss with exercise training on insulin resistance and cardiometabolic adaptations

DL Swift, NM Johannsen, CJ Lavie, CP Earnest… - …, 2016 - Wiley Online Library
Objective To determine response rates for clinically significant weight loss (CWL) following
different aerobic exercise training amounts and whether enhanced cardiometabolic …

Serum bilirubin concentrations and the prevalence of Gilbert syndrome in elite athletes

J Woronyczová, M Nováková, M Leníček… - Sports Medicine …, 2022 - Springer
Objectives Bilirubin is a potent endogenous antioxidant and immunomodulating substance,
which is also implicated in both cell signalling and various metabolic pathways. Mild …

Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells

SO Adeosun, DM Gordon, MF Weeks… - American Journal …, 2018 - journals.physiology.org
Obesity and increased lipid availability have been implicated in the development and
progression of chronic kidney disease. One of the major sites of renal lipid accumulation is …

Bilirubin as a predictor of diseases of civilization. Is it time to establish decision limits for serum bilirubin concentrations?

L Vitek - Archives of biochemistry and biophysics, 2019 - Elsevier
Bilirubin is among the most potent of the endogenous antioxidants. Data developed over the
last three decades have convincingly demonstrated the protective effects of mildly elevated …