Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Diet has an important role in the development of colorectal cancer. In the past few decades,
findings from extensive epidemiologic and experimental investigations have linked …

Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract (GIT),
including Crohn's disease (CD) and ulcerative colitis (UC), which differ in the location and …

Many metals are essential for living organisms, but at higher doses they may be toxic and
carcinogenic. Metal exposure occurs mainly in occupational settings and environmental …

Cancer is a multistage and complex process characterized by molecular alterations that
underlie all three phases of its development:(i) initiation,(ii) promotion and (iii) progression …

Long-term exposure to arsenic (inorganic arsenic) is a world-wide environmental health
concern. Arsenic is classified as the Group 1 human carcinogen by the International Agency …

Oral cancer, included within head and neck cancer, is the sixth most common malignant
neoplasm in the world. The main etiological factors are tobacco and alcohol, although …

Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …

Epigenetic and genetic alterations contribute to cancer initiation and progression.
Epigenetics refers to the study of heritable changes in gene expression without alterations in …

Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but
play an important role in the control of gene expression. In mammals, epigenetic …