The formation of a hierarchical vascular network, composed of arteries, veins, and
capillaries, is essential for embryogenesis and is required for the production of new …

Hematopoietic stem cells (HSCs) sustain blood production throughout life and are of pivotal
importance in regenerative medicine. Although HSC generation from pluripotent stem cells …

We have investigated the developmental relationship of the hemopoietic and endothelial
lineages in the floor of the chicken aorta, a site of hemopoietic progenitor emergence in the …

Hematopoiesis is established from circulating blood stem cells that seed the embryonic
rudiments of blood-forming tissues, a basic notion in developmental hematology. However …

We have previously reported the origin of a class of skeletal myogenic cells from explants of
dorsal aorta. This finding disagrees with the known origin of all skeletal muscle from somites …

Quail-chick intracoelomic grafts of organ rudiments were used to study the origin of
endothelia and haemopoietic cells during avian organogenesis in conjunction with the …

Whether embryonic and adult blood derive from a single (yolk sac) or dual (yolk sac plus
intraembryonic) origin is controversial. Here, we show, in Xenopus, that the yolk sac (VBI) …

A population of hematopoietic progenitors becomes committed within the embryo proper in
the floor of the aorta (P-Sp/AGM in the mouse). In birds, this first aspect of intraembryonic …

The hypothesis that the endothelial and hemopoietic lineages have a common ontogenic
origin is currently being revived. We have shown previously by means of quail/chick …

We have examined the zebrafish embryo to ascertain the location of endocardial and
myocardial progenitors prior to gastrulation, in an attempt to define the earliest stages of …