Unsupervised multi-omics data integration methods: a comprehensive review

N Vahabi, G Michailidis - Frontiers in genetics, 2022 - frontiersin.org
Through the developments of Omics technologies and dissemination of large-scale
datasets, such as those from The Cancer Genome Atlas, Alzheimer's Disease Neuroimaging …

[HTML][HTML] A survey on single and multi omics data mining methods in cancer data classification

Z Momeni, E Hassanzadeh, MS Abadeh… - Journal of Biomedical …, 2020 - Elsevier
Data analytics is routinely used to support biomedical research in all areas, with particular
focus on the most relevant clinical conditions, such as cancer. Bioinformatics approaches, in …

Integrative survival analysis of breast cancer with gene expression and DNA methylation data

I Bichindaritz, G Liu, C Bartlett - Bioinformatics, 2021 - academic.oup.com
Motivation Integrative multi-feature fusion analysis on biomedical data has gained much
attention recently. In breast cancer, existing studies have demonstrated that combining …

Autoencoded DNA methylation data to predict breast cancer recurrence: Machine learning models and gene-weight significance

L Macías-García, M Martinez-Ballesteros… - Artificial Intelligence in …, 2020 - Elsevier
Breast cancer is the most frequent cancer in women and the second most frequent overall
after lung cancer. Although the 5-year survival rate of breast cancer is relatively high …

Robust pathway-based multi-omics data integration using directed random walks for survival prediction in multiple cancer studies

SY Kim, HH Jeong, J Kim, JH Moon, KA Sohn - Biology direct, 2019 - Springer
Background Integrating the rich information from multi-omics data has been a popular
approach to survival prediction and bio-marker identification for several cancer studies. To …

IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma

C Liu, W Zhang, X Zhou, L Liu - Frontiers in Immunology, 2022 - frontiersin.org
Backgrounds IMPDH1, a rate-limiting enzyme in de novos synthesis of guanine nucleotides,
plays an essential role in the growth and progression of certain tumors. However, there is …

Multi-omics data analysis identifies prognostic biomarkers across cancers

E Demir Karaman, Z Işık - Medical Sciences, 2023 - mdpi.com
Combining omics data from different layers using integrative methods provides a better
understanding of the biology of a complex disease such as cancer. The discovery of …

25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes

Y Wang, W Lin, JE Brown, L Chen, WM Pandak… - Journal of lipid …, 2021 - ASBMB
Abstract The oxysterol sulfate, 25-hydroxycholesterol 3-sulfate (25HC3S), has been shown
to play an important role in lipid metabolism, inflammatory response, and cell survival …

Pancancer survival prediction using a deep learning architecture with multimodal representation and integration

Z Fan, Z Jiang, H Liang, C Han - Bioinformatics Advances, 2023 - academic.oup.com
Motivation Use of multi-omics data carrying comprehensive signals about the disease is
strongly desirable for understanding and predicting disease progression, cancer particularly …

Machine learning with the TCGA-HNSC dataset: improving usability by addressing inconsistency, sparsity, and high-dimensionality

MC Rendleman, JM Buatti, TA Braun, BJ Smith… - BMC …, 2019 - Springer
Background In the era of precision oncology and publicly available datasets, the amount of
information available for each patient case has dramatically increased. From clinical …